Endocrine Abstracts

Introduction: The Visceral Adiposity Index (VAI) has been proven to be an indicator of adipose distribution and function that indirectly expresses cardiometabolic risk, in particular in specific populations such as women with polycystic ovary syndrome, acromegaly or type 2 diabetes. Little information is known about its usefulness in the definition of cardiometabolic risk in ageing population.Objective: To study VAI in relation to metabolic and hormonal ...

Aim: To evaluate the diagnostic effectiveness of the first commercially available computer-aided diagnostic (CAD) imaging analysis system.Methods: Ultrasound images of 300 thyroid nodules (135 malignant) acquired prior to surgical treatment were retrospectively reviewed by a thyroid expert, and then the classification of each image was compared to the classification rendered by an image analysis program (AmCAD-UT®). The American Thyroid A...

Aim: To evaluate the long-term efficacy of percutaneous ethanol injection treatment (PEIT) as an alternative to thyroid surgery in symptomatic thyroid cysts with a structured protocol.Methods: Seventy five subjects (48±12 years; 58% women) with symptomatic benign thyroid cysts relapsed after drainage were included. PEIT was conducted using the established procedure in our hospital, and the initial cyst volume, pain perceived by the patient and sympt...

Total vitamin D levels are decreased in obese patients probably due to an increased volume of distribution mechanism. Recently introduced direct assays allow the measurement of free-vitaminD3 levels (fvitD3). Few data are available regarding fvitD3 levels in obese people and the effect of bariatric surgery upon its circulating concentration. We aimed to evaluate fvitD3 in a cohort of obese patients before and after bariatric surgery treatment and its relationship to phosphocal...

Background: Patients with Cushing’s syndrome (CS) in remission show residual cardiometabolic derangements leading to increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis), such as richness, diversity and composition, have been associated with several cardiometabolic risk factors, including obesity, insulin resistance and atherosclerosis. Whether CS patients present with intestinal dysbiosis is currently unknown. Our study was aimed at evalu...

Acromegaly is a rare disease usually diagnosed late in disease evolution. It implies for skeletal changes of most flat bones including those of the skull. Consequently, a progressive facial disfiguration occurs at slow velocity of irreversible nature. Even after curation most of these changes stay for the whole life of the patient.Aim: to study the potential relationship between disfiguring facial modifications and psychosocial and Quality of Life (QoL) ...

Introduction: Previous results of our group, presented in the ECE last year, showed a lower gene expression of proconvertase PC1/3, involved in the processing of POMC, in silent corticotroph tumors (sCT) than in functioning ones (fCT), overall and in microadenomas. The aim of the present study was to quantify the protein expression of convertases involved in the processing of POMC (PC1/3) and in the degradation of ACTH (PC2, CPE and PAM) in a series of CT.</p...

We aimed to assess the effect of sleeve gastrectomy (SG) on the metabolic and gut microbiota profiles in non-diabetic obese patients with different grade of insulin resistance (IR).Methods: Prospective study of 22 morbid non-diabetic obese patients (77.2% women, age 47.13±9.51 years, basal BMI 45.59±4.99 kg/m2, 11 IR and 11 non-IR) undergoing SG. A fasting blood sample was collected at baseline and at 6 months post-SG for the determi...

Introduction: The presence and type of atherosclerotic plaque is associated with future cardiovascular events (CVE). We previously described that increased frequency of plaques is associated with specific features in type 1 diabetes. The aim of the present study was to investigate the characteristics of atherosclerotic plaques in patients with type 1 diabetes mellitus (T1D).Methods: A cross-sectional study of 174 subjects with carotid atherosclerotic pla...

Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients with and without diabetes mellitus (DM). Traditional cardiovascular risk factors fail to fully account for the increase in cardiovascular risk in these patients. The NEFRONA study is a large, multicentre, prospective, observational study that evaluated atheromatous disease (AD) in the carotid and femoral territories in a large cohort of Spanish CKD ...